核酸
纳米技术
DNA纳米技术
DNA
DNA折纸
纳米结构
计算机科学
拓扑(电路)
组合化学
材料科学
化学
数学
生物化学
组合数学
作者
Lu Song,Xiaolei Zuo,Min Li
标识
DOI:10.1002/cplu.202300760
摘要
Nucleic acids are considered as promising materials for developing exquisite nanostructures from one to three dimensions. The advances of DNA nanotechnology facilitate ingenious design of DNA nanostructures with diverse shapes and sizes. Especially, the algebraic topological framework nucleic acids (ATFNAs) are functional DNA nanostructures that engineer guest molecules (e.g., nucleic acids, proteins, small molecules, and nanoparticles) stoichiometrically and spatially. The intrinsic precise properties and tailorable functionalities of ATFNAs hold great promise for biological applications, such as cell recognition and immunotherapy. This Perspective highlights the concept and development of precisely assembled ATFNAs, and outlines the new frontiers and opportunities for exploiting the structural advantages of ATFNAs for biological applications.
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