Remyelination by preexisting oligodendrocytes: Glass half full or half empty?

The central dogma in remyelination states that the primary cellular source for myelin repair are the oligodendrocyte precursor cells. In this issue of Neuron, Mezydlo et al. 1 Mezydlo A. Treiber N. Ullrich Gavilanes E.M. Eichenseer K. Ancău M. Wens A. Ares Carral C. Schifferer M. Snaidero N. Misgeld T. Kerschensteiner M. Remyelination by surviving oligodendrocytes is inefficient in the inflamed mammalian cortex. Neuron. 2023; https://doi.org/10.1016/j.neuron.2023.03.031 Abstract Full Text Full Text PDF Scopus (0) Google Scholar highlight the potential of preexisting oligodendrocytes as an alternative, albeit minor, source for new myelin, with implications for demyelinating disorder research and therapies. The central dogma in remyelination states that the primary cellular source for myelin repair are the oligodendrocyte precursor cells. In this issue of Neuron, Mezydlo et al. 1 Mezydlo A. Treiber N. Ullrich Gavilanes E.M. Eichenseer K. Ancău M. Wens A. Ares Carral C. Schifferer M. Snaidero N. Misgeld T. Kerschensteiner M. Remyelination by surviving oligodendrocytes is inefficient in the inflamed mammalian cortex. Neuron. 2023; https://doi.org/10.1016/j.neuron.2023.03.031 Abstract Full Text Full Text PDF Scopus (0) Google Scholar highlight the potential of preexisting oligodendrocytes as an alternative, albeit minor, source for new myelin, with implications for demyelinating disorder research and therapies. Remyelination by surviving oligodendrocytes is inefficient in the inflamed mammalian cortexMezydlo et al.NeuronApril 17, 2023In BriefMeyzdlo et al. study whether surviving oligodendrocytes contribute to myelin recovery in a multiple sclerosis model. They show that these cells attempt but often fail to remyelinate. Drugs that promote myelin formation by oligodendrocyte precursor cells do not affect surviving oligodendrocytes, indicating that surviving oligodendrocytes require distinct therapeutic targeting. Full-Text PDF