催化作用
反应性(心理学)
化学
酰胺
组合化学
工作(物理)
有机化学
医学
机械工程
工程类
病理
替代医学
作者
Christopher R. Opie,Hidetoshi Noda,Masakatsu Shibasaki,Naoya Kumagai
出处
期刊:Organic Letters
[American Chemical Society]
日期:2023-01-20
卷期号:25 (4): 694-697
被引量:7
标识
DOI:10.1021/acs.orglett.2c04382
摘要
Diboron substructures have emerged as a promising scaffold for the catalytic dehydrative amidation of carboxylic acids and amines. This Letter describes the design, synthesis, and evaluation of the first isolable N(BOH)2 compound as an amidation catalyst. The new catalyst outperforms the previously reported B3NO2 heterocycle catalyst, with respect to turnover frequency, albeit the former gradually decomposes upon exposure to amines. This work opens up an avenue for designing a better catalyst for direct amidation.
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