Ultrasound‐Propelled Penetration of Swimming Nanobowls for Effectively Healing Deep Diabetic Wounds

Abstract Deep diabetic wound healing faces significant challenges due to the incapability of conventional therapies to penetrate deeply into the wounds with high levels of blood sugar and reactive oxygen species (ROS). To address these challenges, especially the deep penetration issue, a new strategy is proposed for effectively healing deep diabetic wounds by spraying ultrasound‐propelled ‘swimming’ nanobowls. The nanobowls are self‐assembled from an amphiphilic polymer P(HAzoMA 24 ‐ stat ‐AAPBA 11 ‐ stat ‐AGA 13 ‐ stat ‐MAA 10 ). The HAzoMA segment can facilitate the formation of nanobowls with ultrasound‐propelled capabilities due to the synergistic effect of π – π interaction and hydrogen bonding. Upon sonication, the nanobowls can conduct directional motion at a speed of 25.9 µm s −1 . The nanobowls can regulate glucose levels due to the dynamic binding between AAPBA and AGA segments. The MAA segment can serve as a nucleation site for in situ decoration with ceria nanoparticles, which have excellent superoxide dismutase mimetic activity to make nanobowls achieve 80% inhibition of ROS. In vivo treatment of deep diabetic wounds proved that the nanobowls can penetrate deeply into skin wounds (up to 720 µm, 10.3‐fold the depth of the group without ultrasound) and heal wounds within 10 days. Overall, this study presents a promising approach for deep diabetic wound healing using ultrasound‐propelled nanobowls.