医学
肠道微生物群
微生物群
病态的
生物信息学
病理生理学
冠状动脉粥样硬化
机制(生物学)
免疫学
肠道菌群
病理
内科学
生物
冠心病
认识论
哲学
作者
Juan C. Salazar,Valery Morillo,María K. Suarez,Ana Castro,Paola Ramírez,Milagros Rojas,Roberto José Añez-Ramos,Luis D’Marco,Marlene Verónica González González,Valmore Bermúdez
出处
期刊:Current Cardiology Reviews
[Bentham Science]
日期:2023-07-01
卷期号:19 (4)
标识
DOI:10.2174/1573403x19666230202164524
摘要
Abstract: Atherosclerosis is one of the most relevant and prevalent cardiovascular diseases of our time. It is one of the pathological entities that increases the morbidity and mortality index in the adult population. Pathophysiological connections have been observed between atherosclerosis and the gut microbiome (GM), represented by a group of microorganisms that are present in the gut. These microorganisms are vital for metabolic homeostasis in humans. Recently, direct and indirect mechanisms through which GM can affect the development of atherosclerosis have been studied. This has led to research into the possible modulation of GM and metabolites as a new target in the prevention and treatment of atherosclerosis. The goal of this review is to analyze the physiopathological mechanisms linking GM and atherosclerosis that have been described so far. We also aim to summarize the recent studies that propose GM as a potential target in atherosclerosis management.
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