A latent profile and network analysis of social isolation in colorectal cancer patients undergoing chemotherapy

This study aims to identify distinct subgroups of social isolation among colorectal cancer patients undergoing chemotherapy, explore the cut-off value and core dimensions within these subgroups, and investigate the potential mechanisms influencing their experiences. The present study employed a cross-sectional survey design involving 256 colorectal cancer patients in Wuxi, conducted between June 2023 and March 2024. Latent profile analysis and receiver operating characteristic curve analyses were performed to identify subgroups of social isolation and to determine cut-off values. Network analysis was conducted to elucidate the dimensions of social isolation and the interrelationships among the associated factors. Two distinct subgroups were identified: Low-Social Isolation and High-Social Isolation, with the latter characterized by social isolation scores of 38 or higher. Loneliness (r strength ​= ​1.965, r closeness ​= ​2.001, r betweenness ​= ​2.375) emerged as the core dimension of social isolation, while family functioning (r strength ​= ​1.405, r closeness ​= ​1.426, r betweenness ​= ​1.241) demonstrated a significant impact on elevated levels of social isolation. This study provides critical tools for identifying patients suffering from high social isolation. It is imperative for health care professionals to acknowledge the central role of loneliness and prioritize it as a critical intervention target for mitigating social isolation. Additionally, family functioning should be regarded as a key intervention component when developing strategies aimed at addressing social isolation.