生物
烟曲霉
曲菌病
微生物学
中性粒细胞胞外陷阱
曲霉
细胞外
分生孢子
体内
真菌
免疫学
细胞生物学
炎症
植物
生物技术
作者
Phillipe de Souza Lima-Gomes,Michelle T. C. Nascimento,Natalia Rocha Nadaes,Sérgio Gaspar de Campos,Rosa Maria Tavares Haido,Maria das Graças Miranda Danelli,Lúcia Helena Pinto-da-Silva,Elvira M. Saraiva
标识
DOI:10.1016/j.micinf.2023.105261
摘要
Aspergillosis is a common fungal disease in avian species, causing high mortality in young chicks in agricultural farms and yards. It is caused by fungi belonging to the genus Aspergillus. Aspergillosis occurs by inhalation of fungal conidia, and in chickens, effective infection control relies on a rapid and large influx of heterophils to the lungs. Heterophils, upon different stimuli, release to the extracellular milieu their chromatin associated with several proteins that ensnare and kill different pathogens similarly to neutrophil extracellular traps. Here, we showed that Aspergillus fumigatus conidia and the peptidogalactomannan (PGM), isolated from the fungus cell wall, induce the release of DNA extracellular traps (DETs) in chicks' blood and lung heterophils. We demonstrated that reactive oxygen species, elastase and peptidyl arginine deiminase (PAD) were involved in DETs extrusion, the occurrence of DETs in the lungs of A. fumigatus-exposed chicks in vivo, and its role in chick survival. These results may contribute to developing more efficient tools for the therapeutic and diagnosis of aspergillosis.
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