粘蛋白
CTCF公司
生物
DNA
遗传学
染色质
基因
转录因子
增强子
作者
Luca Braccioli,Elzo de Wit
标识
DOI:10.1016/j.molcel.2023.07.025
摘要
In this issue, Zhang et al. 1 Zhang H. Shi Z. Banigan E.J. Kim Y. Yu H. Bai X. Finkelstein I.J. CTCF and R-loops are boundaries of cohesin-mediated DNA looping. Mol Cell. 2023; 83https://doi.org/10.1016/j.molcel.2023.07.006 Abstract Full Text Full Text PDF Scopus (1) Google Scholar show that CTCF blocks cohesin-mediated loop extrusion in an orientation-dependent manner. Using single-molecule imaging assays, the authors find that dCas9 and R-loops can also stall extrusion. In this issue, Zhang et al. 1 Zhang H. Shi Z. Banigan E.J. Kim Y. Yu H. Bai X. Finkelstein I.J. CTCF and R-loops are boundaries of cohesin-mediated DNA looping. Mol Cell. 2023; 83https://doi.org/10.1016/j.molcel.2023.07.006 Abstract Full Text Full Text PDF Scopus (1) Google Scholar show that CTCF blocks cohesin-mediated loop extrusion in an orientation-dependent manner. Using single-molecule imaging assays, the authors find that dCas9 and R-loops can also stall extrusion. CTCF and R-loops are boundaries of cohesin-mediated DNA loopingZhang et al.Molecular CellAugust 2, 2023In BriefCTCF and cohesin organize the 3D eukaryotic genome. Zhang et al. report direct single-molecule and structure evidence that CTCF is a polar cohesin barrier. R-loops are also cohesin barriers and likely play a role in organizing the 3D genome. Full-Text PDF
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