前额叶皮质
感觉系统
功能磁共振成像
神经科学
神经影像学
伤害
医学
有害刺激
神经功能成像
心理学
运动皮层
刺激(心理学)
刺激
内科学
认知
认知心理学
受体
作者
MacGregor Hall,Dawson Kidgell,Luke Perraton,Jack Morrissey,Shapour Jaberzadeh
出处
期刊:Pain Medicine
[Oxford University Press]
日期:2021-02-28
卷期号:22 (6): 1399-1410
被引量:10
摘要
Abstract Background Neuroimaging studies show that nociceptive stimuli elicit responses in an extensive cortical network. Functional near-infrared spectroscopy (fNIRS) allows for functional assessment of changes in oxyhemoglobin (HbO), an indirect index for cortical activity. Unlike functional magnetic resonance imaging (fMRI), fNIRS is portable, relatively inexpensive, and allows subjects greater function. No systematic review or meta-analysis has drawn together the data from existing literature of fNIRS studies on the effects of experimental pain on oxyhemoglobin changes in the superficial areas of the brain. Objectives To investigate the effects of experimental pain on brain fNIRS measures in the prefrontal-cortex and the sensory-motor-area; to determine whether there is a difference in oxyhemodynamics between the prefrontal-cortex and sensory-motor-area during pain processing; to determine if there are differences in HbO between patients with centralized persistent pain and healthy controls. Methods Studies that used fNIRS to record changes in oxyhemodynamics in prefrontal-cortex or sensory-motor-cortex in noxious and innoxious conditions were included. In total, 13 studies were included in the meta-analysis. Results Pain has a significantly greater effect on pre-frontal-cortex and sensory-motor areas than nonpainful stimulation on oxyhemodynamics. The effect of pain on sensory-motor areas was greater than the effect of pain on the prefrontal-cortex. There was an effect of centralized pain in the CPP group on oxyhemodynamics from a noxious stimulus compared to control’s response to pain. Conclusions Pain affects the prefrontal and sensory-motor cortices of the brain and can be measured using fNIRS. Implications of this study may lead to a simple and readily accessible objective measure of pain.
科研通智能强力驱动
Strongly Powered by AbleSci AI