材料科学
水解
粘弹性
环氧乙烷
高分子化学
共聚物
自愈水凝胶
缩醛
化学
有机化学
复合材料
聚合物
作者
Jinsu Baek,Seyoung Kim,Iloh Son,Soo-Hyung Choi,Byeong C. Kim
出处
期刊:ACS Macro Letters
[American Chemical Society]
日期:2021-08-05
卷期号:10 (8): 1080-1087
被引量:2
标识
DOI:10.1021/acsmacrolett.1c00413
摘要
While the hydrolytic cleavage of ester groups is widely exploited in degradable hydrogels, the scission in the midst of chain backbones can bring dramatic changes in the mechanical properties of the hydrogels. However, the predictive design of the mechanical profile of the hydrogels is a complex task, mainly due to the randomness of the location of chain scission. To overcome this challenge, we herein present degradable ABA triblock poly(ethylene oxide)-based hydrogels containing an A-block bearing acetal pendant, which provides systematically tunable mechano-temporal properties of the hydrogels. In particular, hydrophobic endocyclic tetrahydropyranyl or exocyclic 1-(cyclohexyloxy)ethyl acetal pendants are gradually cleaved by acidic hydrolysis, leading to the gel-to-sol transition at room temperature. Most importantly, a series of dynamic mechanical analyses coupled with ex situ NMR spectroscopy revealed that the hydrolysis rate can be orthogonally and precisely tuned by changing the chemical structure and hydrophobicity of acetal pendants. This study provides a platform for the development of versatile degradable hydrogels in a highly controllable manner.
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