医学
冠状动脉疾病
颈动脉
冠状动脉
纤维帽
动脉
疾病
心脏病学
脂肪组织
内科学
易损斑块
病理
作者
Fragiska Sigala,Evangelos Oikonomou,Alexios S. Antonopoulos,George Galyfos,Dimitris Tousoulis
标识
DOI:10.1016/j.coph.2017.11.010
摘要
Carotid and coronary artery disease are two major atherosclerotic conditions that have shown an increased prevalence in the last three decades that is associated with high morbidity and mortality. Recent data have revealed that the development of the atherosclerotic plaque — the basic entity in both diseases — may share similar characteristics and mechanisms irrespective of the location site. Even though the biology of atherosclerotic process is similar, there are differences in plaque morphology and characteristics. Indeed, plaque erosion, calcified nodules, fibrous cap thickness and macrophage accumulation may be different in the setting of coronary and carotid artery disease. The perivascular adipose tissue surrounding the coronary arteries (but not carotids) could also affect plaque biology. In this review we focus on comparative the characteristics of both types of atherosclerotic plaques and summarize existing knowledge to provide useful conclusions about current and future treatment strategies.
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