化学
立体专一性
硫脲
海因
有机催化
催化作用
卤素
胺气处理
衍生工具(金融)
有机化学
水溶液
组合化学
对映选择合成
烷基
金融经济学
经济
作者
Gloria Hernández‐Torres,Bin Tan,Carlos F. Barbas
出处
期刊:Organic Letters
[American Chemical Society]
日期:2012-03-23
卷期号:14 (7): 1858-1861
被引量:44
摘要
Organocatalytic stereospecific dibromination of a wide variety of functionalized alkenes was achieved using a stable, inexpensive halogen source, 1,3-dibromo 5,5-dimethylhydantoin, and a simple thiourea catalyst at room temperature. The presence of a tertiary amine enhanced the rate of the dibromination reaction, and yields were good in various solvents, including aqueous solvents. The procedure was extended to alkynes and aromatic rings and to dichlorination reactions by using the 1,3-dichloro hydantoin derivative.
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