Palladium‐Catalyzed ortho‐Selective CH Borylation of 2‐Phenylpyridine and Its Derivatives at Room Temperature

Boron delivery: CH borylation at the ortho-position of aromatic compounds is promoted by the treatment of 2-phenylpyridine, or its derivatives, with 9-borabicyclo[3.3.1]nonane in the presence of a palladium catalyst. This reaction proceeds at room temperature and can be conducted without the palladium catalyst at higher temperatures. In both cases, the regioselectivity is controlled by Lewis acid–base interaction between the boron and nitrogen atoms.