前额叶皮质
多巴胺能
神经科学
睡眠剥夺
多巴胺
心理学
神经可塑性
睡眠神经科学
睡眠(系统调用)
昼夜节律
脑电图
非快速眼动睡眠
认知
计算机科学
操作系统
作者
Mingzheng Wu,Xin Zhang,Sihan Feng,Sara Nicole Freda,Pushpa Kumari,Vasin Dumrongprechachan,Yevgenia Kozorovitskiy
出处
期刊:Neuron
[Elsevier]
日期:2024-01-01
卷期号:112 (1): 141-154.e8
被引量:3
标识
DOI:10.1016/j.neuron.2023.10.002
摘要
The pathophysiology of affective disorders-particularly circuit-level mechanisms underlying bidirectional, periodic affective state transitions-remains poorly understood. In patients, disruptions of sleep and circadian rhythm can trigger transitions to manic episodes, whereas depressive states are reversed. Here, we introduce a hybrid automated sleep deprivation platform to induce transitions of affective states in mice. Acute sleep loss causes mixed behavioral states, featuring hyperactivity, elevated social and sexual behaviors, and diminished depressive-like behaviors, where transitions depend on dopamine (DA). Using DA sensor photometry and projection-targeted chemogenetics, we reveal that elevated DA release in specific brain regions mediates distinct behavioral changes in affective state transitions. Acute sleep loss induces DA-dependent enhancement in dendritic spine density and uncaging-evoked dendritic spinogenesis in the medial prefrontal cortex, whereas optically mediated disassembly of enhanced plasticity reverses the antidepressant effects of sleep deprivation on learned helplessness. These findings demonstrate that brain-wide dopaminergic pathways control sleep-loss-induced polymodal affective state transitions.
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