紫杉醇
胶束
两亲性
PEG比率
纳米颗粒
化学
生物利用度
生物相容性
药物输送
纳米技术
材料科学
组合化学
药理学
水溶液
有机化学
癌症
共聚物
聚合物
医学
内科学
经济
财务
作者
Wenbo Ye,Fangtao Zhu,Yue Cai,Longyu Wang,Guangliang Zhang,Guangkuo Zhao,Xiaohe Chu,Shihua Qi,Yunfeng Yan
标识
DOI:10.1016/j.ijbiomac.2022.09.021
摘要
Polymeric micelle is a promising vehicle to improve the bioavailability and clinical outcomes of paclitaxel (PTX) which has been proven effective in the treatment of a wide range of cancers. However, conventional PTX formulation with the amphiphilic PEG-b-PLA usually suffers from insufficient PTX loading, low stability of PTX-micelles, and rapid PTX release due to low compatibility between PTX and PLA, limiting its clinical application. In this study, a novel nanoparticle platform was developed to improve the stability of PTX-loaded nanoparticles (NPs) and the delivery efficacy of PTX by integrating the flash nanoprecipitation (FNP) technique and a combination of amphiphilic PEG-PLA and super hydrophobic zein. The incorporation of zein led to the formation of distinct hydrophobic interiors of NPs which enhanced the interaction between PTX and NPs, therefore improving the encapsulation efficiency of PTX and sustained drug release compared with PEG-PLA micelles without zein. In addition, FNP allowed facile fabrication of PTX-NPs with smaller sizes and higher stability. These PTX-NPs showed superior sustained release of PTX and good cancer cell-killing in vitro. Among them, PTX-5k-16k-1Z NPs exhibited excellent biosafety and anti-tumor efficacy in a xenograft tumor model in mice, suggesting great potential in the delivery of hydrophobic drugs for cancer therapy.
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