Photocrosslinked gelatin methacryloyl/hyaluronic acid methacryloyl composite hydrogels loaded with bone morphogenetic protein 2-black phosphorus nanosheets for bone regeneration

明胶 自愈水凝胶 透明质酸 再生(生物学) 材料科学 骨形态发生蛋白2 复合数 骨形态发生蛋白 高分子化学 化学工程 复合材料 化学 细胞生物学 生物化学 解剖 医学 生物 体外 工程类 基因
作者
Jiaming Wang,Mingchong Liu,Chensong Yang,Xixi Huang,Chenyu Lin,Yuqian Zhu,Junhua Wang,Hongyi Zhang,Bingdi Chen,Guixin Sun
出处
期刊:Journal of Biomaterials Science-polymer Edition [Taylor & Francis]
卷期号:: 1-23
标识
DOI:10.1080/09205063.2025.2489846
摘要

Black phosphorus nanosheets (BP) have been widely used in bone tissue engineering due to their superior properties and good biocompatibility, as well as the fact that they are composed of only a single element of phosphorus, which is highly homologous to the inorganic components of natural bone. Hydrogels based on gelatin methacryloyl (GelMA)/hyaluronic acid methacryloyl (HAMA) composites were prepared by photocrosslinking. The physicochemical properties of the prepared GelMA/HAMA, GelMA/HAMA/BP, GelMA/HAMA/BMP2 and GelMA/HAMA/BP@BMP2 hydrogels were characterized using Fourier transform infrared spectroscopy (FTIR), dynamic light scattering (DLS), transmission electron microscopy (TEM), and scanning electron microscopy (SEM). In addition, the mechanical properties, swelling rate and degradation rate of the hydrogels were investigated, and the results showed that GelMA/HAMA/BP@BMP2 possessed good physicochemical and mechanical properties, which were suitable for cell adhesion growth and proliferation. BP as a carrier could ensure the stable and sustained release of the bioactive factor: bone morphogenetic protein 2 (BMP2), which could promote the recruitment and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs), and its degradation and binding to surrounding calcium ions can promote biomineralization. Therefore, this BMP2-modified black phosphorus hydrogel system provides a new strategy for bone regeneration.
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