CD177 + neutrophils drive extracellular matrix remodelling and HGF-alpha release in ALPPS-induced liver regeneration

CD177⁺ neutrophils drive liver regeneration by promoting endothelial transmigration, ECM degradation and HGF-α release. These findings reveal a neutrophil-mediated mechanism driving surgical liver regeneration and support the potential of CD177⁺ neutrophil infusion to establish a proregenerative hepatic environment for therapeutic strategies in liver failure.