生物
干细胞
干细胞巢
背景(考古学)
细胞生物学
利基
功能(生物学)
长寿
成体干细胞
干细胞衰老理论
再生(生物学)
神经科学
细胞分化
遗传学
祖细胞
基因
干细胞因子
生态学
古生物学
作者
Joep Beumer,Hans Clevers
标识
DOI:10.1016/j.stem.2023.12.006
摘要
All adult tissues experience wear and tear. Most tissues can compensate for cell loss through the activity of resident stem cells. Although the cellular maintenance strategies vary greatly between different adult (read: postnatal) tissues, the function of stem cells is best defined by their capacity to replace lost tissue through division. We discuss a set of six complementary hallmarks that are key enabling features of this basic function. These include longevity and self-renewal, multipotency, transplantability, plasticity, dependence on niche signals, and maintenance of genome integrity. We discuss these hallmarks in the context of some of the best-understood adult stem cell niches.
科研通智能强力驱动
Strongly Powered by AbleSci AI