活性氧
氧化还原
自行车
氧气
超声波
化学
材料科学
生物物理学
无机化学
生物化学
生物
医学
放射科
有机化学
考古
历史
作者
Xue Wang,Lili Xia,Hui Cheng,K. Li,Wei Feng,Xinyue Dai,Yu Chen
出处
期刊:Nano Today
[Elsevier]
日期:2024-04-01
卷期号:55: 102180-102180
标识
DOI:10.1016/j.nantod.2024.102180
摘要
Reactive oxygen species (ROS) can induce oxidative damage to biomolecules within tumor cells, making them suitable for tumor therapy. However, the effectiveness of these ROS in treating tumor cells is restricted due to their short half-life or short diffusion distance. Sulfate radicals (SO4•–), with a longer half-life and higher oxidation potential, provide a compelling alternative. Herein, we propose an efficient strategy to activate peroxymonosulfate (PMS) and produce SO4•– and •OH by using ultrasound-mediated Cu2+/Cu+ redox cycling, enabling oxygen-independent synergistic tumor therapy. Notably, this redox cycle ensures the continuity of effective Cu+ catalytic sites and prevents adverse effects on healthy tissues. The density functional theory results demonstrate that the decisive copper valence-conversion step is derived from the ultrasound-induced excitations of electrons in spin-down bands of Cu2(OH)PO4. This ultrasound-controlled transition metal valence alteration enables in-situ activation of a nontoxic drug to produce toxic reactive X (X = O/S) species in an O2-independent manner, offering an efficient, adaptable and universal methodology for treating hypoxic tumors in living systems.
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