无血性
被盖腹侧区
吞咽不足
神经科学
慢性应激
下丘脑
抑制性突触后电位
内科学
社会失败
心理学
内分泌学
心情
多巴胺
弓状核
脑刺激奖励
伏隔核
医学
生物
精神科
多巴胺能
作者
Na Qu,Yanlin He,Chunmei Wang,Pingwen Xu,Yongjie Yang,Xing Cai,Hesong Liu,Kaifan Yu,Pei Zhou,Ilirjana Hyseni,Zheng Sun,Makoto Fukuda,Yang Li,Qing Tian,Yong Xu
标识
DOI:10.1038/s41380-019-0506-1
摘要
Chronic stress causes dysregulations of mood and energy homeostasis, but the neurocircuitry underlying these alterations remain to be fully elucidated. Here we demonstrate that chronic restraint stress in mice results in hyperactivity of pro-opiomelanocortin neurons in the arcuate nucleus of the hypothalamus (POMCARH neurons) associated with decreased neural activities of dopamine neurons in the ventral tegmental area (DAVTA neurons). We further revealed that POMCARH neurons project to the VTA and provide an inhibitory tone to DAVTA neurons via both direct and indirect neurotransmissions. Finally, we show that photoinhibition of the POMCARH→VTA circuit in mice increases body weight and food intake, and reduces depression-like behaviors and anhedonia in mice exposed to chronic restraint stress. Thus, our results identified a novel neurocircuitry regulating feeding and mood in response to stress.
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