磁共振成像
材料科学
分子成像
核磁共振
分子探针
荧光
荧光寿命成像显微镜
医学影像学
体内
纳米技术
化学
生物医学工程
光学
物理
医学
放射科
生物化学
生物
生物技术
DNA
作者
Zhao Hai,Hai Zhao,Yi Jiao,Yi Zhu,Chunxia Liu,Feng Li,Yinsong Wang,Zi Gu,Dayong Yang
出处
期刊:Biomaterials
[Elsevier]
日期:2020-10-01
卷期号:256: 120220-120220
被引量:15
标识
DOI:10.1016/j.biomaterials.2020.120220
摘要
Molecular imaging enables noninvasive visualization of cancer-related biological processes for tumor diagnostics; engineering molecular probes for accurate and efficient tumor imaging remains challenge. Herein, by using a biosynthetic strategy, we prepared a tumor-targeted fluorescence/magnetic resonance protein-based probe for dual-modal imaging. The probe was biosynthesized by the fusion of targeting peptide (RGD) with fluorescence protein (RFP) and a small peptide (LBT) that had strong affinity with Gd3+. The probe showed excellent RGD-mediated tumor targeting and stable infrared emission, enabling sensitive tumor-specific imaging. Moreover, efficient T1-weighted magnetic resonance imaging was observed both in vitro and at tumor sites, facilitating high spatial resolution tumor imaging. The simultaneous dual-modal imaging provided more complementary information than each imaging modality. Our work demonstrates the capability of biosynthetic strategy to engineer molecular imaging probes for tumor-targeted multimodal bioimaging, and the probes can be customized to precisely localize and monitor other types of diseases.
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