SeDeM Expert System, an Innovative Tool for Developing Directly Compressible Tablets: A Review
计算机科学
生化工程
工程类
作者
Inderbir Singh,Ajay D. Thakur,Rajni Bala,Reecha Madaan
出处
期刊:Current drug research reviews [Bentham Science] 日期:2021-01-01卷期号:13 (1): 16-24被引量:1
标识
DOI:10.2174/2589977512666200928113716
摘要
Background: SeDeM (Sediment Delivery Model) expert system is a preformulation tool employed for evaluating direct compression suitability of various excipients. SeDeM is a 12 parameters derived diagram and SeDeM-ODT (Sediment Delivery Model-Orodispersible tablets) is a 15 parameters derived diagram that can be used as a research tool for reducing the product development time. The best possible excipients for a specified pharmaceutical active ingredient could be screened for direct compression suitability. Objective: SeDeM expert system has been successfully used and implemented for characterizing galenic properties of pharmaceutical excipients, direct compression suitability of excipients, development of ODT formulations, development of sustained-release formulations, and development of tablets of taste-masked drugs. Conclusion: In the present review paper, the development and applications of SeDeM and SeDeMODT systems have been discussed in detail.