鞭毛
三型分泌系统
分泌物
细胞质
细胞生物学
转运蛋白
效应器
生物
毒力
内膜
ATP酶
化学渗透
支架蛋白
细菌
信号转导
生物化学
基因
遗传学
ATP合酶
线粒体
酶
作者
Manuel Halte,Marc Erhardt
出处
期刊:Biomolecules
[MDPI AG]
日期:2021-01-29
卷期号:11 (2): 186-186
被引量:11
摘要
The bacterial flagellum and the related virulence-associated injectisome system of pathogenic bacteria utilize a type III secretion system (T3SS) to export substrate proteins across the inner membrane in a proton motive force-dependent manner. The T3SS is composed of an export gate (FliPQR/FlhA/FlhB) located in the flagellar basal body and an associated soluble ATPase complex in the cytoplasm (FliHIJ). Here, we summarise recent insights into the structure, assembly and protein secretion mechanisms of the T3SS with a focus on energy transduction and protein transport across the cytoplasmic membrane.
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