A retrospective analysis of treatment of 113 patients with multiple hepatocellular carcinoma

Objective To review and analyze the clinicopathological features,the treatment and the prognosis of patients with multiple hepatocellular carcinoma.Methods The data of 113 patients with multiple hepatocellular carcinoma treated between Jan.to Dec.2009 at the Tianjin Medical University Cancer Hospital were reviewed.The overall survival and the independent risk factors related to survival of these patients were statistically analyzed.Results The 1-,2-,and 3-year overall survival rates of these patients were 36％,19％,and 11％ respectively,and the median survival was 11.6 months.The 1-,2-,and 3-year survival rates of the radical hepatic resection group were 64％,45％,and 27％,which were significantly higher than those of the TACE group (33％,13％,and 7％ respectively),and also those of the supportive treatment group (0％,0％,and 0％ respectively).Univariate analysis showed that age,tumor location,hepatitis background,tumor size,total tumor number,treatment and ALT were prognostic factors of longterm survival for patients with multiple HCC.Multivariate analysis revealed that age,hepatitis,tumor size,tumor number,and type of treatment were independent risk factors related to survival.Conclusions Patients with multiple hepatocellular carcinoma who were in class B or C of the BCLC classification benefited from R0 hepatic resection,if their liver function could tolerate the operation.Age,hepatitis,tumor size,tumor number,treatment were independent risk factors of survival. Key words: Multiple hepatocellular carcinoma;  Liver resection;  Transcatheter arterial chemoembolization;  Supportive treatment ;  Prognosis