[Prospects and reflections on the research and development of next-generation malaria vaccines].

Vaccination is one of the most effective intervention for the containment and elimination of infectious diseases. Recently, the world's first malaria vaccine RTS, S/AS01 was approved by WHO for use among children living in moderately and highly malaria endemic areas of Africa, which brings a hope for the research and development of malaria vaccines. Here, we review the current status of malaria vaccines development and provide a perspective on the development of next-generation malaria vaccines, so as to provide insights into the successful development of malaria vaccines.［摘要］ 疫苗的广泛接种是控制和清除传染病的最有效手段之一。近期, 首款疟疾亚单位疫苗RTS, S/AS01获得了WHO批准, 将在非洲疟疾传播中、高风险地区的儿童中推广使用, 为疟疾疫苗研发带来了新希望。本文结合疟疾疫苗研究现况, 对新一代疟疾疫苗研发进行展望, 为疟疾疫苗的成功研发提供参考。.