化学
重氮
废止
芳基
催化作用
芳构化
烷基化
功能群
全合成
有机化学
立体化学
药物化学
烷基
聚合物
作者
Bin Li,Nana Shen,Kelin Wang,Xuesen Fan,Xinying Zhang
标识
DOI:10.1002/ajoc.202100710
摘要
Abstract In this paper, an efficient synthesis of 5‐carbonyl substituted benzo[ a ]carbazoles via Rh(III)‐catalyzed [5+1] annulation reaction of 2‐aryl‐3‐acyl‐1 H ‐indoles with α‐diazo carbonyl compounds is presented. The cascade process is accomplished by a C−H bond alkylation, cyclization and aromatization. Notably, this novel method features broad substrate compatibility and good functional group tolerance. In addition, the synthetic applications of this protocol have also been demonstrated by gram‐scale synthesis and derivatization to an antitumor agent.
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