Systemic immune-inflammation index (SII) may be an effective indicator in predicting the left ventricular hypertrophy for patients diagnosed with hypertension

Abstract The development of left ventricular hypertrophy (LVH) induced by hypertension is considered as a poor prognosis for patients. Similarly, high values of the systemic immune-inflammation index (SII) can be a leading cause for the increase of mortality and morbidity in cardiovascular events. Within this context, our study aimed to detect the association of SII with LVH caused by hypertension. The study encompassed 150 clients diagnosed with hypertensive in total, and evaluated them as two separate groups with regard to left ventricular mass index (LVMI), including 56 patients (37.3%) with LVH and 94 patients (62.6%) with non-LVH. The SII values regarding the group with LVH was detected remarkably higher than those of the non-LVH group (p<0.001). Additionally, the SII level of clients with eccentric and concentric hypertrophy was detected higher than those of the normal ventricular geometry and concentric remodeling groups. With regard to curve analysis of the receiver-operating characteristic (ROC), SII values above 869.5 predicted LVH with a sensitivity of 82.1% and specificity of 86.2% (AUC: 0.861; 95%CI: 0.792-0.930; p < 0.001). LVH can be predicted independently through the use of SII in clients diagnosed with hypertension, which may be a simple and easily calculable marker for judging LVH. Moreover, SII can serve as an accurate determinant for the prediction of LVH, in comparison to NLR and PLR.