右美托咪定
医学
术后认知功能障碍
麻醉
谵妄
围手术期
心动过缓
镇静
内科学
认知
重症监护医学
心率
血压
精神科
作者
Yixun Tang,Yongsheng Wang,Gaoyin Kong,Yuan Zhao,Lai Wei,Liu Ji-tong
出处
期刊:PubMed
日期:2022-02-28
卷期号:47 (2): 219-225
被引量:11
标识
DOI:10.11817/j.issn.1672-7347.2022.210280
摘要
Postoperative delirium (POD) and postoperative cognitive dysfunction (POCD) are common operative neurocognitive disorders, which places a heavy burden on patients, families and society. Therefore, it is very important to search for preventive drugs. Previous studies have demonstrated that perioperative use of dexmedetomidine resulted in a decrease the incidence of POD and POCD. But the specific effect of dexmedetomidine on elderly patients undergoing hepatic lobectomy and its potential mechanism are not clear. This study aims to evaluate the efficacy of intraoperative use of dexmedetomidine on preventing POD and POCD in elderly patients undergoing hepatic lobectomy and the influence on the balance between proinflammation and anti-inflammation.
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