过氧化氢
化学
检出限
光化学
卟啉
热重分析
吸收(声学)
单线态氧
吸附
过氧化物
分析化学(期刊)
核化学
材料科学
氧气
色谱法
生物化学
有机化学
复合材料
作者
Yu Wang,Xitong Zhou,Wanxin Dong,Qinsong Zhong,Xinxin Mo,He Li
标识
DOI:10.1016/j.bios.2021.113931
摘要
In this work, we synthesized Fe-Tcpp@ICG(ICG, Indocyanine green) with light stimuli-response through 5,10,15,20-tetrakis (4-carboxyphenyl) porphyrin (Fe-Tcpp) loaded ICG by electrostatic adsorption. The morphology and properties of Fe-Tcpp and Fe-Tcpp@ICG were characterised by ultraviolet-visible absorption spectrometer, X-ray diffraction, thermogravimetric analyzer and transmission electron microscope, respectively. A non-enzymatic photoelectrochemical sensor based on Fe-Tcpp@ICG was constructed to quantitatively detect hydrogen peroxide in tumor microenvironment. Under the optimal conditions, the linear range of detecting hydrogen peroxide was 0.01-50 mmol/L with detection limit of 0.2 μmol/L (S/N = 3). This sensor proposed a simple, fast, sensitive and label-free method for the detection of hydrogen peroxide. Moreover, the results also showed that the Fe-Tcpp@ICG can catalyze the decomposition of hydrogen peroxide to generate singlet oxygen, which can kill tumor cells. These indicated that this material was expected to be used for detecting hydrogen peroxide and inhibition of tumor cell growth.
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