Restenosis Animal Model after Carotid Endarterectomy

Objective: To establish an animal model of the restenosis after carotid endarterectomy. Methods: Thirty Japanese white rabbits were operated after 2 weeks fat enriched feeding. The right common carotid arteries of rabbits were merely exposed as the control group. Carotid endarterectomy was performed on the left common carotid arteries in rabbits as the experimental group. Results: Twenty-seven rabbits remained alive no restenosis were observed in the control segments of arteries. Restenosis were observed in all the segments of arteries performed the carotid endarterectomy. Restenosis were mainly caused by the formation of neointima. The neointima area grew consistently in time and reached the peak at 8 weeks after the operation. Conclusion: It is a highly effective and steady animal model of restenosis after carotid endarterectomy and fat enriched feeding.