医学
围手术期
儿科
低出生体重
心室
出生体重
心脏病
回顾性队列研究
队列
心脏外科
三体
前瞻性队列研究
外科
内科学
怀孕
生物
遗传学
作者
Jeffrey B. Anderson,Bradley S. Marino,Sharon Y. Irving,J. Felipe García-España,Chitra Ravishankar,Virginia A. Stallings,Barbara Medoff‐Cooper
出处
期刊:Cardiology in The Young
[Cambridge University Press]
日期:2011-03-09
卷期号:21 (4): 421-429
被引量:34
标识
DOI:10.1017/s1047951111000229
摘要
Abstract Background Adequate nutritional support is essential for normal infant growth and development. Infants with congenital cardiac disease are known to be at risk for growth failure. We sought to describe perioperative growth in infants undergoing surgical repair of two-ventricle congenital cardiac disease and assess for predictors of their pattern of growth. Materials and methods Full-term infants who underwent surgical repair of two-ventricle congenital cardiac disease at a single institution were enrolled in a retrospective cohort study performed following a larger prospective study. Infants with facial, gastrointestinal, or neurologic anomalies, trisomy chromosomal abnormality, birth weight less than 2500 grams, or those transferred to another institution before discharge home were excluded. The primary outcome was change in weight-for-age z score from surgery to discharge. Our secondary outcome variable was post-operative hospital length of stay. Results A total of 76 infants met the inclusion criteria. Medain age at surgery was 5 days with a range from 1 to 44. The median weight-for-age z score at surgery was −0.2 with a range from −2.9 to 2.8 and by discharge had dropped to −1.2 with a range from −3.4 to 1.8. The median change in weight-for-age z score from surgery to discharge was −1.0 with a range from −2.3 to 0.2. Delayed post-operative nutrition (p < 0.001) and reintubation following initial post-operative extubation (p = 0.001) were associated with decrease in weight-for-age z score. Conclusions Infants undergoing repair of two-ventricle congenital cardiac disease had poor growth in the post-operative period. This may be mitigated by early initiation of post-operative nutrition.
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