粪便
益生元
食品科学
盲肠
抗性淀粉
化学
消化(炼金术)
肠道菌群
发酵
淀粉
苷元
盲肠
拟杆菌
橙皮素
短链脂肪酸
橙皮苷
生物
生物化学
丁酸盐
细菌
内科学
微生物学
类黄酮
遗传学
替代医学
糖苷
色谱法
抗氧化剂
医学
有机化学
病理
生态学
作者
Toshihiro Unno,Takayoshi Hisada,Shunsuke Takahashi
标识
DOI:10.1021/acs.jafc.5b02649
摘要
There has been particular interest in the prebiotic-like effects of commonly consumed polyphenols. This study aimed to evaluate the effects of hesperidin (HD) and its aglycone hesperetin (HT), major flavonoids in citrus fruits, on the structure and activity of gut microbiota in rats. Rats ingested an assigned diet (a control diet, a 0.5% HT diet, or a 1.0% HD diet) for 3 weeks. Terminal restriction fragment length polymorphism analysis revealed that the proportion of Clostridium subcluster XIVa in the feces collected at the third week of feeding was significantly reduced by the HT diet: 19.8 ± 4.3% for the control diet versus 5.3 ± 1.5% for the HT diet (P < 0.01). There was a significant difference in the cecal pool of short-chain fatty acids (SCFA), the sum of acetic, propionic, and butyric acids, between the control diet (212 ± 71 μmol) and the HT diet (310 ± 51 μmol) (P < 0.05), whereas the HD diet exhibited no effects (245 ± 51 μmol). Interestingly, dietary HT resulted in a significant increase in the excretion of starch in the feces. HT, but not HD, might reduce starch digestion, and parts of undigested starch were utilized to produce SCFA by microbial fermentation in the large intestine.
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