生物
肠道菌群
斑马鱼
免疫系统
功能(生物学)
分段丝状菌
寄主(生物学)
细胞生物学
免疫学
遗传学
基因
污水处理
活性污泥
工程类
废物管理
作者
Pingping Li,Jinhua Zhang,Xiaoyi Liu,Lu Gan,Yi Xie,Hong Zhang,Jing Si
标识
DOI:10.3389/fmicb.2022.903471
摘要
Gut microbiota has become a topical issue in unraveling the research mechanisms underlying disease onset and progression. As an important and potential "organ," gut microbiota plays an important role in regulating intestinal epithelial cell differentiation, proliferation, metabolic function and immune response, angiogenesis and host growth. More recently, zebrafish models have been used to study the interactions between gut microbiota and hosts. It has several advantages, such as short reproductive cycle, low rearing cost, transparent larvae, high genomic similarity to humans, and easy construction of germ-free (GF) and transgenic zebrafish. In our review, we reviewed a large amount of data focusing on the close relationship between gut microbiota and host health. Moreover, we outlined the functions of gut microbiota in regulating intestinal epithelial cell differentiation, intestinal epithelial cell proliferation, metabolic function, and immune response. More, we summarized major factors that can influence the composition, abundance, and diversity of gut microbiota, which will help us to understand the significance of gut microbiota in regulating host biological functions and provide options for maintaining the balance of host health.
科研通智能强力驱动
Strongly Powered by AbleSci AI