医学
改良兰金量表
溶栓
内科学
白蛋白
球蛋白
接收机工作特性
冲程(发动机)
胃肠病学
生物标志物
外科
缺血性中风
缺血
心肌梗塞
化学
工程类
机械工程
生物化学
作者
Dehao Yang,Jiamin Shen,Honghao Huang,Jianbo Wang,Fangyue Sun,Tian Zeng,Haojie Qiu,Haobo Xie,Yilin Chen,Shengqi Li,Yiqun Chen,Guangyong Chen,Yiyun Weng
摘要
Albumin to globulin ratio (A/G) has been established as a representative biomarker for assessing inflammation and nutritional status. However, the prognostic value of A/G has rarely been reported in acute ischemic stroke (AIS) patients with intravenous thrombolysis (IVT).A total of 311 AIS patients who had undergone IVT and completed 3-month follow-up were retrospectively recruited in this study. Albumin (Alb), globulin (Glb) and A/G on admission, within 24 hours after IVT and on day 7 were recorded. Poor outcome was defined as death or major disability (modified Rankin Scale, 3-6) at 3 months.Among the 311 cases, 260 patients had admission blood samples, 296 cases had blood samples within 24 hours after IVT and 126 cases had blood samples on day 7. The patients with and without available blood samples were well-balanced. During the first 24 h, we observed A/G to increase significantly compared with baseline whereas at day 7 it was almost back to baseline in patients with a poor outcome. Receiver operating characteristic (ROC) curves analysis showed that A/G had a better performance in discriminating patients at high risk and low risk of a poor outcome than either Alb or Glb alone and carried the highest predictive ability on day 7 (AUC = 0.807). Lower 7-day A/G was independently associated with a poor outcome (per-SD increase, OR = 0.182, 95% CI: 0.074-0.446).A/G is an important prognostic indicator for AIS outcomes and merits dynamic monitoring.
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