光遗传学
记忆巩固
海马结构
神经科学
海马体
记忆力减退
抑制性突触后电位
丘脑
分散注意力
背
心理学
生物
解剖
认知
作者
Giulia Torromino,Vittorio Loffredo,D. Cavezza,G Sonsini,Francesca Esposito,Alvaro H. Crevenna,Mariano Gioffrè,M De Risi,Alessandro Treves,Marilena Griguoli,Elvira De Leonibus
标识
DOI:10.1038/s41467-022-31781-8
摘要
Abstract Incidental memory can be challenged by increasing either the retention delay or the memory load. The dorsal hippocampus (dHP) appears to help with both consolidation from short-term (STM) to long-term memory (LTM), and higher memory loads, but the mechanism is not fully understood. Here we find that female mice, despite having the same STM capacity of 6 objects and higher resistance to distraction in our different object recognition task (DOT), when tested over 1 h or 24 h delays appear to transfer to LTM only 4 objects, whereas male mice have an STM capacity of 6 objects in this task. In male mice the dHP shows greater activation (as measured by c-Fos expression), whereas female mice show greater activation of the ventral midline thalamus (VMT). Optogenetic inhibition of the VMT-dHP pathway during off-line memory consolidation enables 6-object LTM retention in females, while chemogenetic VMT-activation impairs it in males. Thus, removing or enhancing sub-cortical inhibitory control over the hippocampus leads to differences in incidental memory.
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