姜黄素
医学
星形胶质细胞
药理学
氧化应激
放射治疗
中枢神经系统
外科
内科学
作者
Yunqian Chang,Guijuan Zhou,Hongmei Wen,Duanqun He,Chenlin Xu,Ya-Rui Chen,Yihui Li,Shuangxi Chen,Zijian Xiao,Ming Xie
标识
DOI:10.4103/1673-5374.346549
摘要
Radiation therapy is considered the most effective non-surgical treatment for brain tumors. However, there are no available treatments for radiation-induced brain injury. Bisdemethoxycurcumin (BDMC) is a demethoxy derivative of curcumin that has anti-proliferative, anti-inflammatory, and anti-oxidant properties. To determine whether BDMC has the potential to treat radiation-induced brain injury, in this study, we established a rat model of radiation-induced brain injury by administering a single 30-Gy vertical dose of irradiation to the whole brain, followed by intraperitoneal injection of 500 μL of a 100 mg/kg BDMC solution every day for 5 successive weeks. Our results showed that BDMC increased the body weight of rats with radiation-induced brain injury, improved learning and memory, attenuated brain edema, inhibited astrocyte activation, and reduced oxidative stress. These findings suggest that BDMC protects against radiation-induced brain injury.
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