细胞生物学
ASK1
激酶
蛋白激酶A
信号转导
蛋白激酶B
p38丝裂原活化蛋白激酶
丝裂原活化蛋白激酶
心肌细胞
心肌细胞
生物
第二信使系统
氧化应激
活性氧
细胞内
丝裂原活化蛋白激酶激酶
生物化学
作者
Peter H. Sugden,Angela Clerk
标识
DOI:10.1089/ars.2006.8.2111
摘要
The toxic effects of oxidative stress on cells (including cardiac myocytes, the contractile cells of the heart) are well known. However, an increasing body of evidence has suggested that increased production of reactive oxygen species (ROS) promotes cardiac myocyte growth. Thus, ROS may be 'second messenger' molecules in their own right, and growth-promoting neurohumoral agonists might exert their effects by stimulating production of ROS. The authors review the principal growth-promoting intracellular signaling pathways that are activated by ROS in cardiac myocytes, namely the mitogen-activated protein kinase cascades (extracellular signal-regulated kinases 1/2, c-Jun N-terminal kinases, and p38-mitogen-activated protein kinases) and the phosphoinositide 3-kinase/protein kinase B (Akt) pathway. Possible mechanisms are discussed by which these pathways are activated by ROS, including the oxidation of active site cysteinyl residues of protein and lipid phosphatases with their consequent inactivation, the potential involvement of protein kinase C or the apoptosis signal-regulating kinase 1, and the current models for the activation of the guanine nucleotide binding protein Ras.
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