胆囊切除术
胆结石
医学
胆囊疾病
胆囊
内科学
代谢综合征
胃肠病学
优势比
普通外科
胆囊炎
脂肪肝
胆囊结石
非酒精性脂肪肝
疾病
风险因素
肥胖
作者
Flavio Nervi,Marco Arrese
摘要
Pathogenesis of nonalcoholic fatty liver (NAFLD) disease and gallbladder (GB) disease secondary to cholesterol gallstones is complex, yet both conditions share similar associated risk factors, most of them related to the metabolic syndrome. Cholecystectomy, the best treatment for GB disease, is one of the most performed abdominal surgeries worldwide. In this issue of the American Journal of Gastroenterology, Ruhl and Everhart, using data from the Third United States National Health and Nutrition Examination Survey (1988-1994), show that NAFLD is associated with cholecystectomy (odds ratio (OR)=2.4; 1.8-3.3), but not with gallstones (OR=1.1; 0.84-1.4). This finding suggests that cholecystectomy may itself represent a risk factor for NAFLD, which is in line with the recently undisclosed role of the GB and bile acids in systemic metabolic regulation. Thus, cholecystectomy may not be innocuous and may have a major impact on public health by contributing to NAFLD development.
科研通智能强力驱动
Strongly Powered by AbleSci AI