Phylogeny of the Serpin Superfamily: Implications of Patterns of Amino Acid Conservation for Structure and Function

James A. Irving1, Robert N. Pike1, Arthur M. Lesk2, and James C. Whisstock1,3 1Department of Biochemistry and Molecular Biology, Monash University, Clayton Campus, Melbourne, Victoria 3168, Australia; 2Wellcome Trust Centre for the Study of Molecular Mechanisms in Disease, Cambridge Institute for Medical Research, University of Cambridge Clinical School, Cambridge CB2 2XY, United Kingdom