Regulated Hepatic Reperfusion Mitigates Ischemia-Reperfusion Injury and Improves Survival after Prolonged Liver Warm Ischemia: A Pilot Study on a Novel Concept of Organ Resuscitation in a Large Animal Model

Regulated hepatic reperfusion mitigates IRI, facilitates liver function recovery, and improves survival after a prolonged period of hepatic warm ischemia. This novel strategy has potential applicability to clinical hepatic surgery and liver transplantation when marginal grafts are used.