转移RNA
核苷酸
化学
灵活性(工程)
核糖核酸
生物物理学
立体化学
生物化学
生物
数学
统计
基因
作者
Yuri Motorin,Mark Helm
出处
期刊:Biochemistry
[American Chemical Society]
日期:2010-05-26
卷期号:49 (24): 4934-4944
被引量:391
摘要
Post-transcriptional ribonucleotide modification is a phenomenon best studied in tRNA, where it occurs most frequently and in great chemical diversity. This paper reviews the intrinsic network of modifications in the structural core of the tRNA, which governs structural flexibility and rigidity to fine-tune the molecule to peak performance and to regulate its steady-state level. Structural effects of RNA modifications range from nanometer-scale rearrangements to subtle restrictions of conformational space on the angstrom scale. Structural stabilization resulting from nucleotide modification results in increased thermal stability and translates into protection against unspecific degradation by bases and nucleases. Several mechanisms of specific degradation of hypomodified tRNA, which were only recently discovered, provide a link between structural and metabolic stability.
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