人工智能
鼻咽癌
支持向量机
计算机科学
接收机工作特性
随机森林
模式识别(心理学)
超参数
特征(语言学)
深度学习
机器学习
放射治疗
医学
内科学
语言学
哲学
作者
Wei Ren,Bin Liang,Chao Sun,Runye Wu,Kuo Men,Huan Chen,Feng Xu,Li’an Hou,Fei Han,Junlin Yi,Jianrong Dai
标识
DOI:10.1016/j.ejmp.2024.103362
摘要
Abstract
Purpose
To establish a deep learning-based model to predict radiotherapy-induced temporal lobe injury (TLI). Materials and methods
Spatial features of dose distribution within the temporal lobe were extracted using both the three-dimensional convolution (C3D) network and the dosiomics method. The Minimal Redundancy-Maximal-Relevance (mRMR) method was employed to rank the extracted features and select the most relevant ones. Four machine learning (ML) classifiers, including logistic regression (LR), k-nearest neighbors (kNN), support vector machines (SVM) and random forest (RF), were used to establish prediction models. Nested sampling and hyperparameter tuning methods were applied to train and validate the prediction models. For comparison, a prediction model base on the conventional D0.5cc of the temporal lobe obtained from dose volume (DV) histogram was established. The area under the receiver operating characteristic (ROC) curve (AUC) was utilized to compare the predictive performance of the different models. Results
A total of 127 nasopharyngeal carcinoma (NPC) patients were included in the study. In the model based on C3D deep learning features, the highest AUC value of 0.843 was achieved with 5 features. For the dosiomics features model, the highest AUC value of 0.715 was attained with 1 feature. Both of these models demonstrated superior performance compared to the prediction model based on DV parameters, which yielded an AUC of 0.695. Conclusion
The prediction model utilizing C3D deep learning features outperformed models based on dosiomics features or traditional parameters in predicting the onset of TLI. This approach holds promise for predicting radiation-induced toxicities and guide individualized radiotherapy.
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