肿瘤微环境
免疫系统
生物
神经科学
胶质瘤
肿瘤细胞
癌症研究
医学
免疫学
作者
Huanming Yang,Zhixing Li,Yichi Zhang,Yuzheng Wu,Zihao Liu,Jianhao Zeng,Zhexue Hao,Xiayu Li,Jiaoyan Ren,Maojin Yao
摘要
Gliomas develop in unique and complicated environments that nourish tumor cells. The tumor microenvironment (TME) of gliomas comprises heterogeneous cells, including brain-resident cells, immune cells, and vascular cells. Reciprocal interactions among these cells are involved in the evolution of the TME. Moreover, the study of attractive therapeutic strategies that target the TME is transitioning from basic research to the clinic. Mouse models are indispensable tools for dissecting the processes and mechanisms leading to TME evolution. In this review, we overview the paradoxical roles of the TME, as well as the recent progress of mouse models in TME research. Finally, we summarize recent advances in TME-targeting therapeutic strategies.
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