化学
三氟甲基化
试剂
三氟甲基
级联
氯化物
组合化学
有机化学
色谱法
烷基
作者
Sitian Yuan,Xuan Li,Zhongzhi Huang,Shuanggen Gui,Yuexing Diao,Yiyuan Peng,Qiuping Ding
标识
DOI:10.1021/acs.joc.2c02100
摘要
A straightforward protocol for the synthesis of 11-trifluoromethylated dibenzodiazepines has been developed via TBAC-induced trifluoromethylation/cyclization of o-isocyanodiaryl amines using Togni's reagent as the trifluoromethyl source. This is the first report on the one-step construction of CF3-containing dibenzodiazepine drug skeletons. Additionally, a series of 11-trifluoromethylated dibenzodiazepines were afforded in moderate to excellent yields under transition-metal-free conditions.
科研通智能强力驱动
Strongly Powered by AbleSci AI