Centella asiatica-Derived Endothelial Paracrine Restores Epithelial Barrier Dysfunction in Radiation-Induced Enteritis

旁分泌信号 癌症研究 放射性肠炎 肠上皮 医学 放射性直肠炎 紧密连接 伤口愈合 上皮 生物 病理 肠炎 免疫学 细胞生物学 内科学 直肠炎 受体 疾病 溃疡性结肠炎
作者
Seo Young Kwak,Won Il Jang,Seung Bum Lee,Min‐Jung Kim,Sunhoo Park,Sang Sik Cho,Hyewon Kim,Sun-Joo Lee,Sehwan Shim,Hyosun Jang
出处
期刊:Cells [Multidisciplinary Digital Publishing Institute]
卷期号:11 (16): 2544-2544 被引量:4
标识
DOI:10.3390/cells11162544
摘要

Radiation-induced enteritis is frequently observed following radiotherapy for cancer or occurs due to radiation exposure in a nuclear accident. The loss of the epithelial integrity leads to 'leaky gut', so recovery of damaged epithelium is an important strategy in therapeutic trials. Centella asiatica (CA), a traditional herbal medicine, is widely used for wound healing by protecting against endothelial damage. In this study, we investigated the radio-mitigating effect of CA, focusing on the crosstalk between endothelial and epithelial cells. CA treatment relieved radiation-induced endothelial dysfunction and mitigated radiation-induced enteritis. In particular, treatment of the conditioned media from CA-treated irradiated endothelial cells recovered radiation-induced epithelial barrier damage. We also determined that epidermal growth factor (EGF) is a critical factor secreted by CA-treated irradiated endothelial cells. Treatment with EGF effectively improved the radiation-induced epithelial barrier dysfunction. We also identified the therapeutic effects of CA-induced endothelial paracrine in a radiation-induced enteritis mouse model with epithelial barrier restoration. Otherwise, CA treatment did not show radioprotective effects on colorectal tumors in vivo. We showed therapeutic effects of CA on radiation-induced enteritis, with the recovery of endothelial and epithelial dysfunction. Thus, our findings suggest that CA is an effective radio-mitigator against radiation-induced enteritis.
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