Sculptra®—History and how it is best used today

Abstract Introduction Sculptra® is an injectable biostimulatory soft tissue filler containing microparticles of poly‐L‐lactic acid (PLLA) that is FDA‐approved for the correction of HIV‐associated facial lipoatrophy and nasolabial fold contour deficiencies and other facial wrinkles in immunocompetent patients. Injectable PLLA has been shown to provide gradual improvement in cutaneous thickness by inciting a subclinical inflammatory response that stimulates increased collagen deposition in the dermis, with results lasting up to 2 years. Discussion The utilization of Sculptra® in aesthetics has expanded to many off‐label indications including panfacial revolumization, improvement in skin quality, and use in various non‐facial sites such as the neck/décolleté, abdomen, arms, hands, thighs, and gluteal area. Clinical experience and scientific investigation have driven changes in the way PLLA is used. Simpler methods of product preparation, improved injection techniques, and attention to appropriate patient selection have led to improved outcomes and ease of use. Conclusion PLLA's long safety history and ability to produce subtle yet significant results through a biostimulatory mechanism make it an attractive and versatile option for cutaneous volume augmentation.