烯丙胺
药物输送
黏膜黏附
接触角
核化学
控制释放
淀粉
化学
聚合物
化学工程
共聚物
材料科学
高分子化学
毒品携带者
有机化学
聚电解质
纳米技术
复合材料
工程类
作者
Muhammad Kaleem Sarwar,Abdul Ghaffar,Qingrong Huang,Miraj Khalid,Aneela Anwar,Abdulfatah Alayoubi,Muhammad Latif
标识
DOI:10.1016/j.ijbiomac.2023.124598
摘要
The blending of natural polysaccharides with synthetic polymers has attracted much attention in drug delivery models owing to their remarkable biodegradable and biocompatible characteristics. This study focuses on the facile preparation of a sequence of composite films having Starch/Poly(allylamine hydrochloride) (ST/PAH) in different compositions to propose a novel drug delivery system (DDS). ST/PAH blend films were developed and characterized. FT-IR evaluation confirmed the involvement of intermolecular H-bonding between the ST and PAH counterparts in blended films. The water contact angle (WCA) ranged from 71° to 100° indicating that all the films were hydrophobic. TPH-1 (90 % ST and 10 % PAH) was evaluated for in vitro controlled drug release (CDR) at 37 ± 0.5 °C in a time-dependent fashion. CDR was recorded in phosphate buffer saline (PBS) and simulated gastric fluid (SGF). In the case of SGF (pH 1.2), the percentile drug release (DR) for TPH-1 was approximately 91 % in 110 min, while the maximum DR was 95 % in 80 min in PBS (pH 7.4) solution. Our results demonstrate that the fabricated biocompatible blend films can be a promising candidate for a sustained-release DDS for oral drug administration, tissue engineering, wound dressings, and other biomedical applications.
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