Current understanding of acute zonal occult outer retinopathy (AZOOR)

医学 神秘的 眼底(子宫) 眼科 玻璃体出血 盲点 视网膜 视网膜脱离 病理 神经科学 替代医学 生物
作者
Rupak Roy,Parthopratim Dutta Majumder
出处
期刊:Indian Journal of Ophthalmology [Medknow]
卷期号:72 (7): 935-937 被引量:1
标识
DOI:10.4103/ijo.ijo_3228_23
摘要

Acute Zonal Occult Outer Retinopathy (AZOOR) is characterized by sudden visual impairment, often presenting with scotoma and photopsia in young to middle-aged adults, showing a female predominance. This condition, distinct from genetic disorders like retinitis pigmentosa, lacks a hereditary basis and exhibits unique fundus changes and imaging features indicative of outer retinal dysfunction. Recent advancements have broadened our understanding, identifying variants like Acute Annular Outer Retinopathy (AAOR) and Multizonal outer retinopathy and retinal pigment epitheliopathy (MORR), each with specific clinical presentations and imaging characteristics. The diagnosis of AZOOR and its variants primarily relies on excluding other conditions through comprehensive evaluation, including imaging and serological testing. Treatment approaches, including the use of corticosteroids and immunosuppressives, remain debated, with some evidence suggesting benefits in the early stages. The prognosis of AZOOR varies, with most patients experiencing stabilization, although complications like choroidal neovascularization may occur, requiring targeted therapy. This manuscript elucidates the complexity of AZOOR, emphasizing the necessity of high clinical suspicion and the role of advanced imaging in diagnosis and management.
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