亲核细胞
化学
电泳剂
吡啶
三氟甲磺酸
卤素
加合物
吡啶类化合物
药物化学
烷基
分解
组合化学
有机化学
催化作用
标识
DOI:10.1002/slct.202302537
摘要
Abstract Herein, we reported a practical and metal‐free synthesis of 2,3‐dihydroindolizines using N ‐alkyl pyridinium salts and electron‐deficient alkenes with ambient air as a sole oxidant. Interestingly, a halogen bond donor (penta‐fluoroiodobenzene 20 mol %) was successfully applied to promote this partial oxidation by slowing down the undesired decomposition processes, probably because of the formation of a halogen‐bonded adduct. Moreover, the C1 position of 2,3‐dihydroindolizines was utilized as a good nucleophile for nucleophilic aromatic substitution with 4‐iodo‐1‐methylpyridin‐1‐ium trifluoromethanesulfonate as electrophile and provided a new‐type dipyridinium compound effectively.
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