黄芩素
黄芩苷
结直肠癌
医学
传统医学
药理学
癌症
癌症研究
化学
内科学
高效液相色谱法
色谱法
作者
Jiamei Wang,Zihong Wu,Jiayuan Peng,Fengming You,Yifeng Ren,Xueke Li,Chong Xiao
标识
DOI:10.3389/fphar.2024.1264418
摘要
The prevalence of colorectal cancer is increasing worldwide, and despite advances in treatment, colorectal cancer (CRC) remains in the top three for mortality due to several issues, including drug resistance and low efficiency. There is increasing evidence that baicalin and baicalein, novel small molecule inhibitor extracts of the Chinese herb Scutellaria baicalensis, have better anti-colorectal cancer effects and are less likely to induce drug resistance in cancer cells. The present review article explains the anti-proliferative properties of baicalin and baicalein in the context of against CRC. Additionally, it explores the underlying mechanisms by which these compounds modulate diverse signaling pathways associated with apoptosis, cell proliferation, tumor angiogenesis, invasion, metastasis, and tumor microenvironment. Moreover, this review article highlights the inhibitory effect of colorectal inflammatory-cancer transformation and the near-term therapeutic strategy of using them as adjuvant agents in chemotherapy.
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